Cannabidiol (CBD) is a phytocannabinoid component of Cannabis sativa that lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC). It has been studied in a wide range of animal models of general anxiety, including the elevated positive labyrinth (EPM), the Vogel conflict test (VCT) and the elevated T labyrinth (ETM). In both healthy volunteers and people diagnosed with social anxiety disorder (SAD), it was found that, compared to the placebo group, a single dose of 400 or 600 mg of CBD significantly reduced subjective anxiety symptoms and decreased cognitive impairment and speech distress. The purpose of the present study was to evaluate the efficacy of CBD treatment for late Japanese adolescents with SAD.
The scores of the participants in the CBD group were smaller than those of the placebo group in the post-intervention measurement (p %3D 0.001), but the scores of the two groups were not statistically significantly different from each other in the pre-intervention measurement (p %3D 0.6). CBD produced no changes in the predicted areas (relative to placebo), but it reduced activation in the left sula, the superior temporal gyrus, and the transverse temporal gyrus. Many claims have been made about CBD's potential to treat various conditions, including cancer and Alzheimer's disease. However, current evidence indicates that CBD has considerable potential as a treatment for multiple anxiety disorders.
It is therefore necessary to continue studying chronic and therapeutic effects in relevant clinical populations. Dosing CBD will require a bit of experimentation because there are many factors that influence how CBD can affect you, such as your genetics and the reason you take it. For example, while 300 milligrams of CBD can reduce a person's anxiety, the same person may not get any relief with a dose of 100 or 900 milligrams. To further complicate matters, this optimal point for CBD dosage may differ not only between symptoms, but also between patients.
There is a lot of evidence that CBD is effective for treating pain symptoms such as topical creams and ointments, oral supplements and even smoking products without causing negative side effects associated with common pain relievers. In healthy people, homeostasis is already well controlled, so taking supplements such as CBD can help maintain this system, but it won't cause any noticeable changes. After observing that rats addicted to heroin were less likely to search for the opioid when treated with CBD, researchers began investigating whether CBD could have the same effect on people with an opioid dependence. This sample size was determined because the current study had been approved by the ethics committee on the condition that, as a pilot study, no more than 20 adolescents took CBD oil. The psychologist who did not know if the bottle contained CBD or not visited the participant's home with the container every afternoon and administered the required amount of prepared oil to the participant using a syringe during the 4-week intervention period.
